Molecular Physiology of Organelles Seminars
(MPO Seminars)


Previous Events:

Date: Apr/21/2024
Title: The role of lipids in mechanotransduction
Speaker: Yixiao Zhang, Ph.D., Interdisciplinary Research Center on Biology and Chemistry, CAS

Date: Mar/30/2024
Title: Trying to understand how endo-lysosomal two-pore channels are activated
Speaker: Sandip Patel, FRSB MAE, University College London

Date: Mar/23/2024
Title: Functional characterization of a lysosomal peptide transporter
Speaker: Bruno Gasnier, Ph.D., French National Centre for Scientific Research (CNRS)

Date: Mar/03/2024
Title: The guardians of mitochondrial metabolism: Solute Carrier SLC25 family transporters
Speaker: Hongying (Hoy) Shen, Ph.D., Department of Cellular and Molecular Physiology, Yale School of Medicine

Date: Feb/25/2024
Title: Innate immune sensing of lysosomal dysfunction in neurons
Speaker: Pinglong Xu, Zhejiang University

Date: Jan/21/2024
Title: Phosphatidylserine at the ER-PM junctions and cell signaling
Speaker: Shmuel Muallem, Ph.D., National Institute of Dental and Craniofacial Research (NIDCR), NIH

Date: Jan/14/2024
Title: Localized Proteasomal Degradation: From Nucleus to the Membranes
Speaker: Xing Guo, Ph.D., Life Sciences Institute, Zhejiang University

Date: Jan/07/2024
Title: Structural and Functional Studies of TRPML1 in Situ
Speaker: Vera Moiseenkova-Bell, Ph.D., University of Pennsylvania

Date: Dec/17/2023
Title: Intracellular electrophysiology
Speaker: Yamuna Krishnan, Ph.D., The University of Chicago

Date: Dec/03/2023
Title: "Manga-Manage" Blood Lipids via COPII Condensation
Speaker: Xiaowei Chen, Ph.D., College of Future Technology, Peking University

Date: Nov/26/2023
Title: Structural basis of sperm activation and motility
Speaker: Jianping Wu, Ph.D., Westlake University

Date: Nov/19/2023
Title: Structure of thermogenin, UCP1
Speaker: Lei Chen, Ph.D., College of Future Technology, Peking University

Date: Nov/12/2023
Title: Mitochondria in stem cell fate and aging
Speaker: Xingguo Liu, Ph.D., Guangzhou Institutes of Biomedicine and Health, CAS

Date: Sept/17/2023
Title: Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
Speaker: Jiyuan Zhang, Ph.D., UT Southwestern Medical Center

Date: Sept/03/2023
Title: The cytoophidium and its kind
Speaker: Ji-Long Liu, Ph.D., School of Life Science and Technology, ShanghaiTech University

Date: Aug/20/2023
Title: A new role of the lysosome in regulating macrophage inflammatory responses
Speaker: Wuyang Wang, M.D., Ph.D., Department of Anesthesiology,
Xuzhou Medical University

Date: Aug/13/2023
Title: Human STING is a proton channel
Speaker: Bingxu Liu, Ph.D., MIT

Date: July/30/2023
Title: The biogenesis of migrasome
Speaker: Li Yu, Ph.D., School of Life Sciences, Tsinghua University

Date: July/09/2023
Title: The Regulation of Necrosome
Speaker: Wei Mo, Ph.D., State key laboratory of cellular stress biology, Xiamen university

Date: July/02/2023
Title: Identification of an organellar mechanosensor
Speaker: Kai Li, Ph.D., University of California San Francisco

Date: June/25/2023
Title: TM9SF4: an organellar protein with multifaceted functions
Speaker: Xiaoqiang Yao, Ph.D., School of Biomedical Sciences, The Chinese University of Hong Kong

Date: June/15/2023
Title: Journal of Cell Biology Publishing Seminar
Speaker: Andrea Marat, Ph.D., Senior Scientific and Reviews Editor, Journal of Cell Biology, Rockefeller University Press and Hong Zhang, Ph.D., Editorial Board Member, Journal of Cell Biology, Institute of Biophysics, CAS

Date: May/21/2023
Title: Regulation of macropinocytosis
Speaker: Huaqing Cai, Ph.D., Institute of Biophysics, Chinese Academy of Sciences

Date: May/15/2023
Title: Endolysosomal Ca2+ Channels as Novel Drug Targets
Speaker: Grimm, Christian, Ph.D., Walther Straub Institute for Pharmacology and Toxicology, Ludwig Maximilians University of Munich (LMU), Munich, Germany and Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Section of Immunology, Infection and Pandemic Research (IIP), Munich, Germany

Date: May/7/2023
Title: GPCR Signaling: Structure, Lipid, Drug Design
Speaker: Yan Zhang, Ph.D., Department of Biophysics, Liangzhu Laboratory, Center for Structural Pharmacology and Therapeutics Development, Zhejiang University School of Medicine

Date: April/16/2023
Title: Lipid-dependent gating of voltage-gated ion channels
Speaker: Qiu-Xing Jiang, Ph.D., Hauptman-Woodward Medical Research Institute/SUNY-Buffalo and University of Florida

Date: April/2/2023
Title: The sperm CatSper calcium channels
Speaker: Jean-Ju Chung, Ph.D., Dept. of Cellular & Molecular Physiology, Yale School of Medicine

Date: Mar/19/2023
Title: Voltage Gating Mechanism of Ion Channels
Speaker: Jiangtao Guo, Ph.D., School of Medicine, Zhejiang University

Date: Mar/12/2023
Title: Golgi Defect as a Major Contributor to Lysosomal Dysfunction and Neurodegeneration
Speaker: Yanzhuang Wang, Ph.D., Dept. of Molecular, Cellular and Developmental Biology (MCDB), Dept. of Neurology, Umich

Date: Mar/5/2023
Title: Expanding the optogenetic and chemogenetic toolbox
Speaker: Yubing Zhou, M.D., Ph.D. Center for Translational Cancer Research, Institute of Biosciences and Technology, Department of Translational Medical Sciences, College of Medicine, Texas A&M University

Date: Feb/26/2023
Title: The Lysosome in Nutrient Sensing and Cellular Growth Control
Speaker: Roberto Zoncu, Ph.D., Molecular and Cell Biology Department, UC Berkeley

Date: Feb/19/2023
Title: Regulation of Cholesterol Metabolism by Nutrients
Speaker: Baoliang Song, Ph.D., Taikang Center for Life and Medical Sciences, Wuhan University

Date: Feb/12/2023
Title: Liquid-Liquid Phase Separation in Autophagy
Speaker: Hong Zhang, Ph.D., Institute of Biophysics, Chinese Academy of Sciences

Date: Jan/29/2023
Title: Biochemical Dissection and Functional Analysis of Autophagy
Speaker: Qing Zhong, Ph.D., Key Laboratory of "Cell Differentiation and Apoptosis" of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiaotong University, School of Medicine

Date: Jan/07/2023
Title: TMEM16 ion channels and lipid scramblases from molecules to disease
Speaker: Huanghe Yang, Ph.D., Department of Biochemistry, Duke University & Yang Zhang, Ph.D., Institute of Molecular Physiology, Shenzhen Bay Laboratory

Date: Dec/11/2022
Title: The late stage of autophagy
Speaker: Yueguang Rong, Ph.D., School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology

Date: Dec/4/2022
Title: The Primary Cilium is a Specialized Calcium Signaling Organelle
Speaker: Markus Delling, Ph. D., UCSF

Date: Dec/4/2022
Title: Subcellular Electrical Signals in Tissue Homeostasis
Speaker: Bimal N. Desai, Ph. D., School of Medicine, University of Virginia

Date: Nov/20/2022
Title: Fixing injured lysosomes: The PITT pathway to the rescue
Speaker: Jay Tan, Ph. D., University of Pittsburgh

Date: Nov/20/2022
Title: PI4P exchange at endoplasmic reticulum–autolysosome contacts is essential for autophagy and neuronal homeostasis
Speaker: Chao Tong, Ph. D., Zhejiang University

Date: Nov/13/2022
Title: The cytoskeleton integrates endothelial metamorphoses to blood flow
Speaker: SERGIO GRINSTEIN, Ph.D., Department of Biochemistry, University of Toronto

Date: Nov/6/2022
Title: Lysosomal TRPML1 channel: from cell physiology to human diseases
Speaker: XIANPING DONG Ph.D., Dalhousie University

Date: Oct/30/2022
Title: From cradle to grave: the mechanisms underlying lysosome biogenesis and quality control
Speaker: Xi Yang, Ph. D., Department of MCDB, Umich

Date: Oct/30/2022
Title: Gating of TRPV ion channels by endogenous ligands
Speaker: Fan Yang, Ph. D., Zhejiang University

Date: Oct/23/2022
Title: Structure and Function of the Tubular ER Network
Speaker: JUNJIE HU Ph.D., Institute of Biophysics, CAS

Date: Oct/16/2022
Title: Structural Basis of Lysosomal Membrane Proteins
Speaker: XIAOCHUN LI Ph.D., Department of Molecular Genetics, UTSW

Date: Oct/9/2022
Title: Lysine sensing and transport influences Ypq1 recognition by a ubiquitin ligase complex
Speaker: Felichi (Peach) Arines, Ph. D., Umich & Broad Institute of MIT and Harvard

Date: Oct/9/2022
Title: Mini but Mighty, Microproteins in Mitochondria
Speaker: Shan Zhang, Ph. D.,School of Medicine, Zhejiang University

Date: Sept/25/2022
Title: Feeling Force with PIEZOs
Speaker: BAILONG XIAO, Ph.D., Tsinghua University

Date: Sep/11/2022
Title: Primary cilia, a short circuit to the nucleus
Speaker: DAVID E. CLAPHAM, MD, Ph.D., HHMI, Janelia Research Campus

Date: Sep/4/2022
Title: Overcoming physical resolution limits of fluorescence microscopes with sparse deconvolution
Speaker: LIANGYI CHEN,Ph.D., School of Future Technology, Peking University

Date: Aug/28/2022
Title: Protein pleiotropy: mechanism and opportunity for disease therapy with minimal on-target side effect
Speaker: MICHAEL X ZHU,Ph.D., Department of Integrative Biology and Pharmacology, McGovern Medical School, UT Health

Date: Aug/21/2022
Title: Identification of the chloride channel CLN7 and its role in lysosomal physiology
Speaker: Chunlei Cang, Ph. D., School of Basic Medical Sciences, University of Science and Technology of China

Date: Aug/21/2022
Title: A sword with two blades: applying fluorescent cAMP to study HCN channel biophysics
Speaker: Lei Zhou, Ph. D., Shen Zhen Bay Laboratory, Institute of Molecular Physiology

Date: Aug/7/2022
Title: Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair
Speaker: Yuwei Huang, Ph. D., School of Basic Medical Sciences, Xi’an Jiaotong University

Date: Aug/7/2022
Title: Epidermal plasma membrane repair in C. elegans
Speaker: Suhong Xu , Ph. D., School of Medicine, Zhejiang University

Date: Jul/24/2022
Title: Synaptic vesicles, LDCVs and new fluorescent sensors
Speaker: YULONG LI, Ph.D., School of Life Sciences, Peking University

Date: Jul/10/2022
Title: Mitochondrial Quality Control: Novel Mechanisms of Mitophagy and Beyond
Speaker: Han-Ming Shen, Ph.D., Chair Professor and Head, Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau

Date: Jun/19/2022
Title: The Acid Gate in the Lysosome
Speaker: Meiqin Hu, Ph. D., Liangzhu laboratory & Zhejiang University Medical Center

Date: Jun/19/2022
Title: Lysosome Lipid Signaling from The Periphery to Neurons Regulates Longevity
Speaker: Marzia Savini, Graduate Program in Developmental Biology, Baylor College of Medicine

Date: Jun/12/2022
Title: Molecular Physiology of Lysosomes
Speaker: HAOXING XU, Ph.D., Professor, Department of MCDB, UMich & LiangZhu Laboratory, Zhejiang University Medical Center

Date: May/22/2022
Title: Redefining the Mechanism of Action of Chemical Uncouplers for a New Generation of Antiobesogenic Drugs
Speaker: AMBRE M BERTHOLET, Ph.D., Assistant Professor, Department of Physiology, David Geffen School of Medicine at UCLA

Date: May/8/2022
Title: Lipid synthesis in ER membrane: mechanism of SCD1 and DGAT1
Speaker: MING ZHOU, Ph. D., Biochemistry and Molecular Biology, Baylor College of Medicine

Date: Apr/17/2022
Title: A ubiquitin and ESCRT-dependent pathway regulates lysosome membrane composition
Speaker: MING LI, Ph. D., Molecular Cellular and Developmental Biology Department, University of Michigan

Date: Apr/10/2022
Title: CCT2 is a new type of autophagy receptor for clearance of solid protein aggregates
Speaker: LIANG GE, Ph. D., School of Life Sciences, Tsinghua University

Date: Mar/20/2022
Title: Next-generation targeting has organelle-level precision
Speaker: YAMUNA KRISHNAN, Ph. D., Department of Chemistry, The University of Chicago

Date: Mar/6/2022
Title: Distinct Mechanisms Regulate Two Pore Channel 2 Gating Sensitivity to Its Agonist PI(3,5)P2
Speaker: Qiaochu Wang, Ph. D., Beijing Children’s Hospital Capital Medical University

Date: Mar/6/2022
Title: Ammonia generated via glutaminolysis tunes lysosomal pH to control the lysosomal degradation capacity and mTORC1 activation during amino acid shortage
Speaker: Jian Xiong, Ph. D., Department of Chemical Engineering, Stanford University

Date: Feb/12/2022
Title: Structural mechanism of allosteric activation of Trpml1 by PI(3,5)P2 and rapamycin
Speaker: Ninghai Gan, Ph.D., The University of Texas Southwestern Medical Center

Date: Feb/12/2022
Title: Disruption of ER ion homeostasis maintained by an ER anion channel leads to ALS-like pathology
Speaker: Yichang Jia, Ph.D., School of Medicine, Tsinghua University