Molecular Physiology of Organelles

Postdoctoral Research Positions Open

slideshow 2019
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Featured Papers

Ma D, Hu M, Yang X, Liu Q, Ye F, Cai W, Wang Y, Xu X, Chang S, Wang R, Yang W, Ye S, Su N, Fan M, Xu H, Guo J. (2024). "Structural basis for sugar perception by Drosophila gustatory receptors." Science: eadj2609.

Hu, M., Li, P., Wang, C., Feng, X., Geng, Q., Chen, W., Marthi, M., Zhang, W., Gao, C., Reid, W., Swanson, J., Du, W., Hume, R. and Xu,. H. (2022). "Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes." Cell 185(13): 2292-2308.

Li, P., Hu, M., Wang, C., Feng, X., Zhao, Z., Yang, Y., Sahoo, N., Gu, M., Yang, Y., Xiao, S., Sah, R., Cover, T. L., Chou, J., Geha, R., Benavides, F., Hume, R. I. and Xu, H. (2020). "LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses." Proc Natl Acad Sci U S A 117(46): 29155-29165

Li, X., Rydzewski, N., Hider, A., Zhang, X., Yang, J., Wang, W., Gao, Q., Cheng, X. and Xu, H. (2016). "A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation." Nat Cell Biol 18(4): 404-417.

Cheng, X., Zhang, X., Gao, Q., Ali Samie, M., Azar, M., Tsang, W. L., Dong, L., Sahoo, N., Li, X., Zhuo, Y., Garrity, A. G., Wang, X., Ferrer, M., Dowling, J., Xu, L., Han, R. and Xu, H. (2014). "The intracellular Ca(2)(+) channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy." Nat Med 20(10): 1187-1192.

Wang, X., Zhang, X., Dong, X. P., Samie, M., Li, X., Cheng, X., Goschka, A., Shen, D., Zhou, Y., Harlow, J., Zhu, M. X., Clapham, D. E., Ren, D. and Xu, H. (2012). "TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes." Cell 151(2): 372-383. Evaluated by F1000.

Cheng, X., Jin, J., Hu, L., Shen, D., Dong, X. P., Samie, M. A., Knoff, J., Eisinger, B., Liu, M. L., Huang, S. M., Caterina, M. J., Dempsey, P., Michael, L. E., Dlugosz, A. A., Andrews, N. C., Clapham, D. E. and Xu, H. (2010). "TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation." Cell 141(2): 331-343.

Dong, X. P., Cheng, X., Mills, E., Delling, M., Wang, F., Kurz, T. and Xu, H. (2008). "The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel." Nature 455(7215): 992-996. Evaluated by F1000.